Basic Information
VIS ID
TVIS44019972
Fusion event
HTLV-1-UNC5D integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr8
Cytoband
p12
Reference genome
GRCh37/hg19
Start
35615052/35757534 (Hg38)
End
35615052/35757534 (Hg38)
Orient
-
Location type
Intronic
Target gene
UNC5D
miRNAs that regulate target gene
hsa-mir-124-3p ; hsa-mir-3680-3p ; hsa-mir-557 ; hsa-mir-507 ; hsa-mir-450b-5p ; hsa-mir-527 ; hsa-mir-518a-5p ; hsa-mir-548aw ; hsa-mir-5195-3p ; hsa-mir-145-5p ; hsa-mir-4328 ; hsa-mir-129-5p
Nearest miRNA
hsa-mir-124-1/Upstream/5800186; hsa-mir-10400/Downstream/5513514;
Nearest TSS
ENST00000518652/Upstream/33383; ENST00000524167/Downstream/104589;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/520941, chr8-CpG: 351/Downstream/1936892
Nearest cancer related gene
UNC5D(TSG, No orient, 0)
Upstream sequence
aatggccagctcctccatttatttcaacgtttggctcaaatactacctcccctagtaatgtctagactcctttcctggtctgtcctcccatctgggtcag
Downstream sequence
gggcaccttctgtctttcttaacctcctaggcattcatgtatggtaatagatactatattagaacaatgcctagtgtccagaccctttcacaacattgta
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
Curate