Basic Information
VIS ID
TVIS44019981
Fusion event
HTLV-1-KAT6A integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr8
Cytoband
p11.21
Reference genome
GRCh37/hg19
Start
41792653/41935135 (Hg38)
End
41792653/41935135 (Hg38)
Orient
-
Location type
Intronic
Target gene
KAT6A
miRNAs that regulate target gene
hsa-mir-425-5p ; hsa-mir-21-5p ; hsa-mir-877-3p ; hsa-mir-296-3p ; hsa-mir-193b-3p ; hsa-mir-190a-3p ; hsa-mir-1277-5p ; hsa-mir-5011-5p ; hsa-mir-576-5p ; hsa-mir-6867-5p ; hsa-mir-3134 ; hsa-mir-8082 ; hsa-mir-4534 ; hsa-mir-511-3p ; hsa-mir-580-5p ; hsa-mir-574-5p ; hsa-mir-6505-5p ; hsa-mir-2681-5p ; hsa-mir-6866-3p ; hsa-mir-188-5p ; hsa-mir-6791-5p ; hsa-mir-4292 ; hsa-mir-4308 ; hsa-mir-223-5p
Nearest miRNA
hsa-mir-124-1/Upstream/274627; hsa-mir-10400/Downstream/961062;
Nearest TSS
ENST00000518652/Upstream/38373; ENST00000521235/Downstream/23228;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/37403, chr8-CpG: 183/Downstream/115720
Nearest cancer related gene
KAT6A(OG, No orient, 0)
Upstream sequence
gtgacatattctaagtcacacagtgaattggcagaactatgaaagaatcctggtcAACATTATGTTATCAGACACTAGTCAGAACCAATTCAAGActacc
Downstream sequence
atcatcagctgcatgtctgtgggaagttactctacatttcagtttcatcatctgtaaaatggagatgaACTTTATAAAGAGGCAAATAAGTAGTAAGCAG
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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