Basic Information
VIS ID
TVIS44019982
Fusion event
HTLV-1-PLAT integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr8
Cytoband
p11.21
Reference genome
GRCh37/hg19
Start
42048606/42191088 (Hg38)
End
42048606/42191088 (Hg38)
Orient
+
Location type
Intronic
Target gene
PLAT
miRNAs that regulate target gene
hsa-mir-204-5p ; hsa-mir-21-5p ; hsa-mir-335-5p
Nearest miRNA
hsa-mir-124-1/Upstream/530580; hsa-mir-10400/Downstream/705109;
Nearest TSS
ENST00000518652/Upstream/2599; ENST00000518983/Downstream/2639;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/37508, chr8-CpG: 50/Downstream/80083
Upstream sequence
cctggccgtgctgctggcggctgtgtgaccctgggcaagccacttgctctctcctgggctctgccttttgatctgtataaccaggaccttgggccagtgg
Downstream sequence
ccgccccccccagcccCCGCTAGGTTGTGATCCCTGACAGCCTGGCTCCTTGGGGGGGAACACCTGTTTCTGCTCCCCTCAGAATCAGAACCCGCCCAGT
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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