Basic Information
VIS ID
TVIS44020013
Fusion event
HTLV-1-TOX integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr8
Cytoband
q12.1
Reference genome
GRCh37/hg19
Start
59991399/59078840 (Hg38)
End
59991399/59078840 (Hg38)
Orient
+
Location type
Intronic
Target gene
TOX
miRNAs that regulate target gene
hsa-mir-26b-5p ; hsa-mir-223-3p
Nearest miRNA
hsa-mir-124-1/Upstream/16182565; hsa-mir-10400/Downstream/2635948;
Nearest TSS
ENST00000518652/Upstream/418996; ENST00000523683/Downstream/40200;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/418873, chr8-CpG: 175/Downstream/38735
Upstream sequence
tggaactcggtaatggacagaggttggaacagtttggagggctcagaagaagacaggaagatgaagaaaagtgtataacttcttaaagattgattaaatg
Downstream sequence
tttgtgaccaaaatgctgacggagatagagacaatgaagtctaggctactgaggtctcagatggaaatgaggaacataattgggaactacagcaaaggtc
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
Curate