Basic Information
VIS ID
TVIS44020015
Fusion event
HTLV-1-TOX integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr8
Cytoband
q12.1
Reference genome
GRCh37/hg19
Start
60022647/59110088 (Hg38)
End
60022647/59110088 (Hg38)
Orient
+
Location type
Intronic
Target gene
TOX
miRNAs that regulate target gene
hsa-mir-26b-5p ; hsa-mir-223-3p
Nearest miRNA
hsa-mir-124-1/Upstream/16213813; hsa-mir-10400/Downstream/2604700;
Nearest TSS
ENST00000518652/Upstream/450244; ENST00000523683/Downstream/8952;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/450121, chr8-CpG: 175/Downstream/7487
Upstream sequence
CTTTAAGTAGTTCTTAAAAGATTAGTTTTGCAGTAAATTTTTGAGAGTTACCTTGAAAAATAACAGCATAATTTATTTCAAAAAGCTTAATTTTGGGAGA
Downstream sequence
GGAAAGATTATCCCATTAGCCTTAGTAACTGAACATAGCTCTGAGAGTCCATTATGAACAGTCTTTTATGCCCTGGCAGGAAGTCATTAACATAAAATAA
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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