Proximate region of VIS (GRCh38)VISEnhancerEnhancer/PromoterPromoterGene84368848317736838649883297088339969834289283491768371538837472083679158369976835174183534098340439834162483620768363005836308883639508377310
Basic Information
VIS ID
TVIS44020041
Fusion event
HTLV-1-PRAG1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr8
Cytoband
p23.1
Reference genome
GRCh37/hg19
Start
8234826/8377310 (Hg38)
End
8234826/8377310 (Hg38)
Orient
+
Location type
Exonic
Target gene
PRAG1
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-1207-5p ; hsa-mir-1910-3p ; hsa-mir-2682-5p ; hsa-mir-3179 ; hsa-mir-3202 ; hsa-mir-34b-5p ; hsa-mir-4423-3p ; hsa-mir-449c-5p ; hsa-mir-4524a-3p ; hsa-mir-4524b-3p ; hsa-mir-4688 ; hsa-mir-4747-5p ; hsa-mir-4763-3p ; hsa-mir-486-3p ; hsa-mir-5196-5p ; hsa-mir-5681a ; hsa-mir-6511a-5p ; hsa-mir-6743-5p ; hsa-mir-6797-5p ; hsa-mir-6808-5p ; hsa-mir-6879-5p ; hsa-mir-6893-5p ; hsa-mir-885-3p ; hsa-mir-940 ; hsa-mir-9500
Nearest miRNA
hsa-mir-3674/Upstream/288221; hsa-mir-10400/Downstream/671135;
Nearest TSS
ENST00000518652/Upstream/150696; ENST00000524073/Downstream/4437;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/58051, chr8-CpG: 88/Downstream/8739
Upstream sequence
GGGGCTGGGGCTCCCCCGTCAGCCCAAGGCATCTGCTAGGGGTCACCCCTGGGCAGCCAGGGTCCTGCTGCTTCTCTGGGGCAGGTTCCTTCATGAGGGA
Downstream sequence
GCAGTAATCACTCTCGAGGTGGGGGACGAAGGGGCTACTGGCGCCGCTGCCGCTGCCGCTGCCACAAGAGAGGCCGTCGGAAGAAATGGCAGCCTCCGAG
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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