Basic Information
VIS ID
TVIS44020045
Fusion event
HTLV-1-LRRCC1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr8
Cytoband
q21.2
Reference genome
GRCh37/hg19
Start
86037566/85125331 (Hg38)
End
86037566/85125331 (Hg38)
Orient
+
Location type
Intronic
Target gene
LRRCC1
miRNAs that regulate target gene
hsa-mir-215-5p ; hsa-mir-192-5p
Nearest miRNA
hsa-mir-12123/Upstream/4883858; hsa-mir-10400/Downstream/6080154;
Nearest TSS
ENST00000518652/Upstream/16669; ENST00000521234/Downstream/51710;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/17702, chr8-CpG: 113/Downstream/51635
Upstream sequence
TTTTTGGGTGTCAGACCCTTTTCAGTATCTAAAAAAATTTACAGGTCTTCTCAAAGAAGCCTATTTTTACACTCAAAAAAATGTATATATTTCAAGGTTT
Downstream sequence
TCATGGACTTTCCTGAAACTCAATTTTGGACCACTGGATCCCAGATTAAGAGGTGTTCAAggccgggcgcggtggctcacgcctgtaatcccagcacttt
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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