Basic Information
VIS ID
TVIS44020056
Fusion event
HTLV-1-RBM12B-AS1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr8
Cytoband
q22.1
Reference genome
GRCh37/hg19
Start
94752431/93740203 (Hg38)
End
94752431/93740203 (Hg38)
Orient
+
Location type
ncRNA_exonic
Fragile sites / regions
FRA8B
Target gene
RBM12B-AS1
Nearest miRNA
hsa-mir-12123/Upstream/710364; hsa-mir-10400/Downstream/175819;
Nearest TSS
ENST00000518652/Upstream/1012; ENST00000523945/Downstream/515;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/39086, chr8-CpG: 44/Downstream/544
Upstream sequence
TTCCCCTGCAGAAAATAATCTACACCAACCCATAATTATTCTTTACGATGATCCACCTTTTATAATGTAGATGTTTAAAATAAAAACCAAAGGAATGACC
Downstream sequence
AATGAGAGCCACAGTCCCTAGGAAGAACTGTAAATGAAGACGAATCCACATGGCACAGGATTTCTCCCAACATCCTCAAACGGGAATCATCCGAAGGCAT
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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