Basic Information
VIS ID
TVIS44020060
Fusion event
HTLV-1-STK3 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr8
Cytoband
q22.2
Reference genome
GRCh37/hg19
Start
99451506/98439278 (Hg38)
End
99451506/98439278 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA8B
Target gene
STK3
miRNAs that regulate target gene
hsa-mir-141-3p ; hsa-mir-9-5p ; hsa-mir-128-3p ; hsa-mir-215-5p ; hsa-mir-192-5p ; hsa-mir-133b
Nearest miRNA
hsa-mir-12123/Upstream/45540; hsa-mir-10400/Downstream/1097358;
Nearest TSS
ENST00000518652/Upstream/2609; ENST00000517397/Downstream/87648;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/11081, chr8-CpG: 90/Downstream/385955
Nearby gene
KCNS2(+8483) ;
Upstream sequence
gatacagggatattttatctccagtgcccaatacaatgcctggcacagaataaatgctgacaaataataaatgaaACGAGGTCAGAAGGGCCTTGTCATT
Downstream sequence
GCCCTTCTGGATAAATTGCGGGTCCCTGTGGAGTCGATTTGACCTGGTACATAGCTGCATCAAGAGTCAGGAGTTTCAGGGCACCGACATCCTTAGCAAA
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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