Basic Information
VIS ID
TVIS44020061
Fusion event
HTLV-1-STK3 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr8
Cytoband
q22.2
Reference genome
GRCh37/hg19
Start
99530465/98518237 (Hg38)
End
99530465/98518237 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA8B
Target gene
STK3
miRNAs that regulate target gene
hsa-mir-141-3p ; hsa-mir-9-5p ; hsa-mir-128-3p ; hsa-mir-215-5p ; hsa-mir-192-5p ; hsa-mir-133b
Nearest miRNA
hsa-mir-12123/Upstream/124499; hsa-mir-10400/Downstream/1018399;
Nearest TSS
ENST00000518652/Upstream/81568; ENST00000517397/Downstream/8689;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/90040, chr8-CpG: 90/Downstream/306996
Upstream sequence
AATAAATTATAACATGTTGACAAGAAACCACATACTGCACCTGTGCTTTCTATCTTAATTAATCCAATAAGTACAGGCCTGCTCACTTAAATTTGTAAGG
Downstream sequence
GAAATGATGATATAATGAGTTTTAACTTAAGGTATTAATTACCTAAATAAGCAGAATTAGCTTAATGTTTCAGTAGACTTTGCCTAGACACAACCACCAA
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
Curate