Basic Information
VIS ID
TVIS44020062
Fusion event
HTLV-1-INVS integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr9
Cytoband
q31.1
Reference genome
GRCh37/hg19
Start
102896096/100133814 (Hg38)
End
102896096/100133814 (Hg38)
Orient
-
Location type
Intronic
Target gene
INVS
miRNAs that regulate target gene
hsa-mir-6867-5p ; hsa-mir-574-5p ; hsa-mir-4648 ; hsa-mir-3689f ; hsa-mir-3689e ; hsa-mir-3689b-5p ; hsa-mir-3689a-5p ; hsa-mir-92b-5p ; hsa-mir-190b ; hsa-mir-190a-5p ; hsa-mir-511-3p ; hsa-mir-3161 ; hsa-mir-6818-5p
Nearest miRNA
hsa-let-7a-1/Upstream/1904597; hsa-mir-12126/Downstream/6467114;
Nearest TSS
ENST00000422679/Upstream/29275; ENST00000398977/Downstream/174055;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/34419, chr9-CpG: 93/Downstream/218499
Upstream sequence
atattggtacattcactctcgcaaactatctgactatatctgccaaagctacacacacacacacacacacacacacacacacacacacacatacacacat
Downstream sequence
ccctcatctcaattcatgctcccagccccggtaatacctaagaaaaataagtgcctctttctactagaagacatgtatgagaattacatgatagttttat
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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