Basic Information
VIS ID
TVIS44020082
Fusion event
HTLV-1-DAB2IP integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr9
Cytoband
q33.2
Reference genome
GRCh37/hg19
Start
124514021/121751742 (Hg38)
End
124514021/121751742 (Hg38)
Orient
-
Location type
Intronic
Target gene
DAB2IP
miRNAs that regulate target gene
hsa-mir-338-3p ; hsa-mir-18a-3p ; hsa-let-7b-5p ; hsa-mir-32-5p ; hsa-mir-92a-3p ; hsa-mir-92b-3p ; hsa-mir-1229-5p ; hsa-mir-1293 ; hsa-mir-197-5p ; hsa-mir-3132 ; hsa-mir-3144-5p ; hsa-mir-3191-3p ; hsa-mir-3194-3p ; hsa-mir-326 ; hsa-mir-330-5p ; hsa-mir-363-5p ; hsa-mir-3907 ; hsa-mir-4257 ; hsa-mir-4483 ; hsa-mir-4651 ; hsa-mir-4652-5p ; hsa-mir-4667-5p ; hsa-mir-4700-5p ; hsa-mir-5691 ; hsa-mir-608 ; hsa-mir-637 ; hsa-mir-6732-5p ; hsa-mir-6745 ; hsa-mir-6748-5p ; hsa-mir-6752-5p ; hsa-mir-6756-5p ; hsa-mir-6766-5p ; hsa-mir-6769a-5p ; hsa-mir-6769b-5p ; hsa-mir-6805-3p ; hsa-mir-6810-5p ; hsa-mir-6842-5p ; hsa-mir-6847-5p ; hsa-mir-7110-5p ; hsa-mir-7155-5p ; hsa-mir-8065 ; hsa-mir-8089
Nearest miRNA
hsa-let-7a-1/Upstream/1506692; hsa-mir-12126/Downstream/368340;
Nearest TSS
ENST00000422679/Upstream/770; ENST00000459906/Downstream/8598;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/15059, chr9-CpG: 23/Downstream/8225
Nearest cancer related gene
DAB2IP(TSG, No orient, 0)
Upstream sequence
CTTGTGCGAGGGGCCTTTCAGGAGGGCTCGGACACCAGCTTGAGGCATCTGGGACTTGATTATCTTACAGGCCATGAGGCGAGAGAGGAGGGACAGGAGT
Downstream sequence
GAGGCCATGCCAGGCGGAGTGGCTTGTTCAGTGGAGGGTGCTGCTTTGGTCTAGACAGGAGAAGGCCAGTGGAACTCCCATTCCCCTCTGCCCTCCCATG
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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