Basic Information
VIS ID
TVIS44020086
Fusion event
HTLV-1-MAPKAP1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr9
Cytoband
q33.3
Reference genome
GRCh37/hg19
Start
128420965/125658686 (Hg38)
End
128420965/125658686 (Hg38)
Orient
+
Location type
Intronic
Target gene
MAPKAP1
miRNAs that regulate target gene
hsa-mir-375 ; hsa-mir-26b-5p
Nearest miRNA
hsa-let-7a-1/Upstream/964888; hsa-mir-12126/Downstream/2032001;
Nearest TSS
ENST00000422679/Upstream/976; ENST00000492314/Downstream/11159;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/249813, chr9-CpG: 58/Downstream/48140
Upstream sequence
AGGGCACTAATGAacaaggtagacactgaataaattttgttgcatgaatgaatGAATGATTGAAATAATTCAGATTAAAATTATTAAATCTGAATCTTCA
Downstream sequence
GTTCTTATTCATTAGTGAACCAAGACAAGTTCCGTAACTTTTCAAAGATCATTTAATTCTCTAAATCAATTGGAATATCAATCAAGGTGGCGGTAGCTAG
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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