Basic Information
VIS ID
TVIS44020090
Fusion event
HTLV-1-FIBCD1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr9
Cytoband
q34.12
Reference genome
GRCh37/hg19
Start
133783723/130908336 (Hg38)
End
133783723/130908336 (Hg38)
Orient
-
Location type
Intronic
Target gene
FIBCD1
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-1908-5p ; hsa-mir-6810-5p ; hsa-mir-491-5p ; hsa-mir-92a-2-5p ; hsa-mir-4652-5p ; hsa-mir-3191-3p ; hsa-mir-3144-5p ; hsa-mir-92b-5p ; hsa-mir-6717-5p ; hsa-mir-6770-5p ; hsa-mir-4285 ; hsa-mir-134-5p ; hsa-mir-181d-3p ; hsa-mir-1915-3p ; hsa-mir-3118 ; hsa-mir-3164 ; hsa-mir-412-3p ; hsa-mir-4270 ; hsa-mir-4300 ; hsa-mir-4441 ; hsa-mir-5591-5p ; hsa-mir-6075 ; hsa-mir-617 ; hsa-mir-6505-3p ; hsa-mir-6726-5p ; hsa-mir-6754-3p ; hsa-mir-6754-5p ; hsa-mir-6764-5p ; hsa-mir-6820-3p ; hsa-mir-7113-5p ; hsa-mir-920 ; hsa-mir-3170 ; hsa-mir-4259 ; hsa-mir-4433a-3p ; hsa-mir-4514 ; hsa-mir-4692 ; hsa-mir-4722-5p ; hsa-mir-5572 ; hsa-mir-571 ; hsa-mir-615-5p ; hsa-mir-6737-5p ; hsa-mir-6808-5p ; hsa-mir-6812-5p ; hsa-mir-6819-5p ; hsa-mir-6855-5p ; hsa-mir-6893-5p ; hsa-mir-7704 ; hsa-mir-940
Nearest miRNA
hsa-let-7a-1/Upstream/281973; hsa-mir-126/Downstream/2037371;
Nearest TSS
ENST00000422679/Upstream/11524; ENST00000421067/Downstream/21643;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/3789, chr9-CpG: 24/Downstream/4949
Upstream sequence
GGTGGTGCGGCAGAGGAGGGACTGGCGCTGTTGACATTCCTGTCAGGGCTCGTCTGCAGGATGCTGGAATGAGGACCTGCTTAAATGCTTCCTCCCGCAT
Downstream sequence
CATCTGCAGCTGCTGATAGATTTCAATTAAGATACCATGAGCACGGGCATCACCGCTGCTCCAGGGGGTGGGTGGTGGCGAGGGCATGCCTTGGCCCTGC
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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