Basic Information
VIS ID
TVIS44020095
Fusion event
HTLV-1-COL5A1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr9
Cytoband
q34.3
Reference genome
GRCh37/hg19
Start
137710782/134818936 (Hg38)
End
137710782/134818936 (Hg38)
Orient
-
Location type
Intronic
Target gene
COL5A1
miRNAs that regulate target gene
hsa-mir-26b-5p ; hsa-mir-744-5p ; hsa-mir-145-5p ; hsa-mir-143-3p ; hsa-mir-543 ; hsa-mir-6780a-5p ; hsa-mir-6779-5p ; hsa-mir-3689c ; hsa-mir-3689b-3p ; hsa-mir-3689a-3p ; hsa-mir-30b-3p ; hsa-mir-1273h-5p ; hsa-mir-6778-5p ; hsa-mir-6825-5p ; hsa-mir-1233-5p ; hsa-mir-6799-5p ; hsa-mir-6883-5p ; hsa-mir-6785-5p ; hsa-mir-4728-5p ; hsa-mir-149-3p ; hsa-mir-6878-5p ; hsa-mir-7106-5p ; hsa-mir-5703 ; hsa-mir-4516 ; hsa-mir-4434 ; hsa-mir-3934-5p ; hsa-mir-764 ; hsa-mir-125a-3p ; hsa-mir-6760-5p ; hsa-mir-29b-1-5p ; hsa-mir-29b-3p
Nearest miRNA
hsa-let-7a-1/Upstream/439464; hsa-mir-126/Downstream/30362;
Nearest TSS
ENST00000422679/Upstream/9975; ENST00000460264/Downstream/3986;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/491, chr9-CpG: 15/Downstream/8501
Upstream sequence
CTGTGTTTCAGGGAGAACAAGGTCTCCCAGGATCCCCAGGCCCGGACGGTCCCCCCGGCCCCATGGTGAGTCACATTCCTCATGGTGAGCATAGCGGGTG
Downstream sequence
GGATGACTTCGCCACCCAAAGCCCCAAGGATGAGGACTCTGATCCCCCTGCCTCCTCCCACAGGGTCCCCCAGGACTTCCCGGCCTCAAAGGAGATTCTG
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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