Basic Information
VIS ID
TVIS44020099
Fusion event
HTLV-1-RABL6 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr9
Cytoband
q34.3
Reference genome
GRCh37/hg19
Start
139727831/136833379 (Hg38)
End
139727831/136833379 (Hg38)
Orient
-
Location type
Intronic
Target gene
RABL6
miRNAs that regulate target gene
hsa-mir-1226-3p ; hsa-mir-425-5p ; hsa-mir-484 ; hsa-mir-191-5p ; hsa-mir-222-3p ; hsa-mir-10a-5p ; hsa-let-7e-5p
Nearest miRNA
hsa-let-7a-1/Upstream/2356; hsa-mir-3621/Downstream/53354;
Nearest TSS
ENST00000422679/Upstream/4907; ENST00000435930/Downstream/1792;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/1391, chr9-CpG: 19/Downstream/5859
Upstream sequence
GACCTGAACCTCCTCGCCCTGGGCTGCCCCAGCTGGATCTGGGGGACCTGAACCTCCTCGCCCTGGGCTGCCCCGCCTGGGTCTGGGGGACCTGAACCTC
Downstream sequence
CTTGCCTGGGCTGCCCCGCCTGGGTCTGGGGGACCTGAACCTCCTCGCCCTGGGCTGCCCCAGCTGGGTCTGGGGGACCTGTACCTCCTCGCCCTGGGCT
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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