Basic Information
VIS ID
TVIS44020104
Fusion event
HTLV-1-PSIP1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr9
Cytoband
p22.3
Reference genome
GRCh37/hg19
Start
15470069/15470071 (Hg38)
End
15470069/15470071 (Hg38)
Orient
+
Location type
Intronic
Target gene
PSIP1
miRNAs that regulate target gene
hsa-mir-193b-3p ; hsa-mir-375 ; hsa-mir-155-5p ; hsa-mir-1-3p
Nearest miRNA
hsa-mir-101-2/Upstream/9462167; hsa-let-7a-1/Downstream/3103235;
Nearest TSS
ENST00000422679/Upstream/22959; ENST00000474193/Downstream/2679;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/46869, chr9-CpG: 107/Downstream/40107
Nearest cancer related gene
PSIP1(OG, No orient, 0)
Upstream sequence
CTTTCCTTCATCTTTATTCTGCCTATCAAATGTTAACAAAAATATTTCAACACATTGGAATTTTGTGACTAAATGCCCACAATCCCTATGTAAAAGCTAA
Downstream sequence
AAATGTTTTCCTTAAAATAAGTCAATAGCCTAGACTGCAAAGGAACTGACTGTAGCTCTTAGAATGGTGCAGTTCCGTAGCATAAATATAAGCAAAACTC
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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