Basic Information
VIS ID
TVIS44020109
Fusion event
HTLV-1-ADAMTSL1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr9
Cytoband
p22.2
Reference genome
GRCh37/hg19
Start
18307681/18307683 (Hg38)
End
18307681/18307683 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA9G
Target gene
ADAMTSL1
miRNAs that regulate target gene
hsa-mir-132-3p ; hsa-mir-25-3p ; hsa-mir-3202 ; hsa-mir-3689d ; hsa-mir-377-5p ; hsa-mir-4533 ; hsa-mir-6079 ; hsa-mir-6086 ; hsa-mir-6133 ; hsa-mir-6134 ; hsa-mir-6851-5p ; hsa-mir-6880-5p ; hsa-mir-6894-5p ; hsa-mir-7154-3p ; hsa-mir-765 ; hsa-mir-766-5p ; hsa-mir-7847-3p
Nearest miRNA
hsa-mir-101-2/Upstream/12299779; hsa-let-7a-1/Downstream/265623;
Nearest TSS
ENST00000422679/Upstream/401120; ENST00000431052/Downstream/54537;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/400193, chr9-CpG: 20/Downstream/130875
Nearby gene
ADAMTSL1(+166398) ;
Upstream sequence
aaaaaaggctaagaaaggcattacataatggtaaagggatcaattcaacaagaagagctaactatcctaaatatatatgcacccaatacaggagcaccca
Downstream sequence
gattcataaagcaagttcttagagacagacaaagagacttagactcccacataataatagtgggagactttaacaccccactgtcaatattacacagatc
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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