Basic Information
VIS ID
TVIS44020134
Fusion event
HTLV-1-PGM5 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr9
Cytoband
q21.11
Reference genome
GRCh37/hg19
Start
71009371/68394455 (Hg38)
End
71009371/68394455 (Hg38)
Orient
-
Location type
Intronic
Target gene
PGM5
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-124-3p
Nearest miRNA
hsa-mir-101-2/Upstream/27160620; hsa-let-7a-1/Downstream/2415520;
Nearest TSS
ENST00000422679/Upstream/36603; ENST00000587852/Downstream/2069;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/36767, chr9-CpG: 122/Downstream/310327
Upstream sequence
acttgggaggctgaggcagaaaaatcgcttgaacccaggagacagaggttgcagtgagccgataccatgccattgcactccagcctgggcaacaagagaa
Downstream sequence
caagagtgaaactctgtctcaacaacaacaacaaaaaaaTACTGAAGGGCCATAACACGTGGTTCTAAATGAGATACTACATTGGGCAAACCATTCAAAA
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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