Basic Information
VIS ID
TVIS44020149
Fusion event
HTLV-1-TJP2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr9
Cytoband
q21.11
Reference genome
GRCh37/hg19
Start
71802416/69187500 (Hg38)
End
71802416/69187500 (Hg38)
Orient
+
Location type
Intronic
Target gene
TJP2
miRNAs that regulate target gene
hsa-mir-124-3p ; hsa-mir-203a-3p ; hsa-mir-193b-3p ; hsa-mir-215-5p ; hsa-mir-34a-5p ; hsa-mir-192-5p
Nearest miRNA
hsa-mir-101-2/Upstream/27953665; hsa-let-7a-1/Downstream/1622475;
Nearest TSS
ENST00000422679/Upstream/13206; ENST00000498204/Downstream/17298;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/12874, chr9-CpG: 19/Downstream/60534
Upstream sequence
GTGTTGTCAAAACTGGGATGCTGTCATTTCTGTTTCTCTGTCTCTTTCGTCTGTTCCAATTTGAGATATACTGACTATGTTAGTGTAGTCTGCTACATGG
Downstream sequence
ATAGTCCTTTATCTTTCAGCAACATAAGCAACATAAGCTTTTTGACTGAGACGAGCGTAATCAAAAGGAATGCTGGGAAACAGTGAACTGTAAAAAATGT
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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