Basic Information
VIS ID
TVIS44020150
Fusion event
HTLV-1-APBA1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr9
Cytoband
q21.12
Reference genome
GRCh37/hg19
Start
72081483/69466567 (Hg38)
End
72081483/69466567 (Hg38)
Orient
-
Location type
Intronic
Target gene
APBA1
miRNAs that regulate target gene
hsa-mir-450a-1-3p ; hsa-mir-7977 ; hsa-mir-8059 ; hsa-mir-4471 ; hsa-mir-1292-5p ; hsa-mir-6774-5p ; hsa-mir-635 ; hsa-mir-3667-3p ; hsa-mir-6734-3p ; hsa-mir-4667-3p ; hsa-mir-1470 ; hsa-mir-2114-5p ; hsa-mir-212-3p ; hsa-mir-132-3p ; hsa-mir-3199 ; hsa-mir-365a-5p ; hsa-mir-365b-5p ; hsa-mir-574-5p ; hsa-mir-6818-5p ; hsa-mir-6867-5p ; hsa-mir-8052 ; hsa-mir-892a
Nearest miRNA
hsa-mir-101-2/Upstream/28232732; hsa-let-7a-1/Downstream/1343408;
Nearest TSS
ENST00000422679/Upstream/1045; ENST00000429567/Downstream/1381;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/54055, chr9-CpG: 16/Downstream/49404
Upstream sequence
TCAGGCAGAAGGCAGTGGTCAGAGGTGTTCGCATCTGCAGGCTTCCCCTGCACTCTGGTGGCACTCGGCCTCTGACACTGTCCTCTCCTTGGGCACACCC
Downstream sequence
CACACACTCCCTGGCTTGCTTTGTCATTCCCTCATTCATACTGCTGAGCTTGAGAACAAGGATCTCACTTTATCAGCTACTGTTTTTCCTCCCTGCCAAG
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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