Basic Information
VIS ID
TVIS44020160
Fusion event
HTLV-1-TLE1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr9
Cytoband
q21.32
Reference genome
GRCh37/hg19
Start
84276705/81661790 (Hg38)
End
84276705/81661790 (Hg38)
Orient
+
Location type
Intronic
Target gene
TLE1
miRNAs that regulate target gene
hsa-mir-657 ; hsa-mir-191-5p ; hsa-mir-615-3p ; hsa-mir-423-3p ; hsa-mir-942-5p
Nearest miRNA
hsa-mir-101-2/Upstream/10851706; hsa-let-7a-1/Downstream/2307958;
Nearest TSS
ENST00000422679/Upstream/41233; ENST00000413050/Downstream/25578;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/2088145, chr9-CpG: 255/Downstream/25434
Nearest cancer related gene
TLE1(OG, No orient, 0)
Upstream sequence
AAACAGATAACCTCTAAATCCCTTCTGACTAGAAGTTTCTGAGTCTGTGAAATGACAACCTTAAATCCCCCCCCCAAAAAAAATGTACACAGAAACCTCA
Downstream sequence
CCGGCAACCAAACAAAAATGTAAATTTTGTTGTAAGTAAGGTAGGTCATTCAGGAAGTTAAGGCAATTtttaaaaaattaacaaaatccaatgatgaagc
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
Curate