Basic Information
VIS ID
TVIS44020171
Fusion event
HTLV-1-ROR2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr9
Cytoband
q22.31
Reference genome
GRCh37/hg19
Start
94578346/91816064 (Hg38)
End
94578346/91816064 (Hg38)
Orient
-
Location type
Intronic
Target gene
ROR2
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-let-7f-5p ; hsa-mir-451a
Nearest miRNA
hsa-mir-101-2/Upstream/179703; hsa-let-7a-1/Downstream/476394;
Nearest TSS
ENST00000422679/Upstream/40283; ENST00000457003/Downstream/71135;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/82583, chr9-CpG: 21/Downstream/84219
Nearest cancer related gene
ROR2(TSG, No orient, 0)
Upstream sequence
Gtcacccccaaagcctgtgcatctcctctctcagaaaacccttctccataaacggtaagcagcctcaccttctacccagtggctcaaggcaaacacccga
Downstream sequence
tgccatctggctccctcttccctggattcctcaagccggtccatcggtcatcagttctatcccaatacaggtctcggagccagtgtcccctgtctttctc
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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