Basic Information
VIS ID
TVIS44020172
Fusion event
HTLV-1-CENPP integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr9
Cytoband
q22.31
Reference genome
GRCh37/hg19
Start
95375571/92613289 (Hg38)
End
95375571/92613289 (Hg38)
Orient
+
Location type
UTR3
Target gene
CENPP
miRNAs that regulate target gene
hsa-let-7e-5p ; hsa-mir-3194-5p ; hsa-mir-210-5p ; hsa-mir-1273f ; hsa-mir-4708-5p ; hsa-mir-6088 ; hsa-mir-4770 ; hsa-mir-143-3p ; hsa-mir-4319 ; hsa-mir-4324 ; hsa-mir-125b-5p ; hsa-mir-6769a-3p ; hsa-mir-125a-5p ; hsa-mir-6858-3p
Nearest miRNA
hsa-mir-101-2/Upstream/85231; hsa-let-7a-1/Downstream/981552;
Nearest TSS
ENST00000422679/Upstream/2745; ENST00000494669/Downstream/7041;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/286965, chr9-CpG: 89/Downstream/56241
Upstream sequence
AGGAACATGCAATTTTATTCAATATAAACATTTGCTATTTTCTGCTTAGAAACCACACCCTGAAGACGTGCTGTCTATGCAGTTATGGCACATTATATGG
Downstream sequence
AAACTCTCATGACATGAAAAATAAATACAACTAGTTAAGTATAAAATGCCAAATAAAAGTGACACGTACAATGTGGTTTATAAAAATAAGCTTAACATCT
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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