Basic Information
VIS ID
TVIS44020184
Fusion event
HTLV-1-TBC1D2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr9
Cytoband
q22.33
Reference genome
GRCh37/hg19
Start
101011217/98248935 (Hg38)
End
101011217/98248935 (Hg38)
Orient
+
Location type
Intronic
Target gene
TBC1D2
miRNAs that regulate target gene
hsa-mir-373-3p ; hsa-mir-17-5p
Nearest miRNA
hsa-let-7a-1/Upstream/19718; hsa-mir-12126/Downstream/8351993;
Nearest TSS
ENST00000422679/Upstream/19852; ENST00000610463/Downstream/6645;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/56052, chr9-CpG: 96/Downstream/6165
Upstream sequence
CGTGGGTTCCCTTTGATCTTTCTTGGCTCTGCGGAGACCGTTGTTTAGGTAAAGCATAAAATAAAGTTGTAAATCCTTAAAAGCAGGAGAGAACATGCCT
Downstream sequence
TGCAGATTGCTCAAGAGCAGTGACGAGACACTTTTTACCAGAAGTCTCTGACTCAAAGTCAGACATGGGTCAGGAGGTTTTCAACGACATGGGAGCGGGC
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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