Basic Information
VIS ID
TVIS44020186
Fusion event
HTLV-1-SUFU integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr10
Cytoband
q24.32
Reference genome
GRCh37/hg19
Start
104370144/102610387 (Hg38)
End
104370144/102610387 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA10D ; FRA10A ; FRA10B
Target gene
SUFU
miRNAs that regulate target gene
hsa-mir-378a-3p ; hsa-mir-378a-5p ; hsa-mir-93-3p ; hsa-mir-214-3p ; hsa-mir-181a-2-3p ; hsa-mir-3914 ; hsa-mir-4252 ; hsa-mir-6719-3p ; hsa-mir-6788-3p ; hsa-mir-6840-3p ; hsa-mir-873-5p ; hsa-mir-888-3p
Nearest miRNA
hsa-mir-107/Upstream/173803; hsa-mir-1307/Downstream/783866;
Nearest TSS
ENST00000439456/Upstream/19578; ENST00000646349/Downstream/31923;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/105989, chr10-CpG: 321/Downstream/31677
Nearest cancer related gene
SUFU(TSG, No orient, 0)
Upstream sequence
taggctgaggcaggagaattgcttgaacctgggaggcggaggttgcagtgagccgagatcacaccattgcactccagcctgggcgtcgcagcaagactct
Downstream sequence
gtctcaaaaaaaaaaagaaaaagagaaaagaaatgcttacctgcccaagtagacaaaggaagtgctgtagaccttatataggcggggtttagcaagatgt
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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