VISDB Viral Integration Site DataBase

VIS ID

TVIS44020187

Fusion event

HTLV-1-CNNM2 integration

Validated

No

Detection method

HTS

Data source

download(RID)

Sample type

Disease

HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)

Quality evaluation

Normal

Reported year

2017

PubMed ID

Virus name

HTLV-1

Reference genome

Not given

Chromosome

chr10

Cytoband

q24.32

Reference genome

Start

End

104750830/102991073 (Hg38)

Orient

-

Location type

Intronic

Fragile sites / regions

FRA10D ; FRA10A ; FRA10B

Target gene

miRNAs that regulate target gene

hsa-mir-128-3p ; hsa-mir-124-3p ; hsa-mir-103a-3p ; hsa-mir-26b-5p ; hsa-mir-16-5p ; hsa-mir-107 ; hsa-mir-635 ; hsa-mir-4524a-5p ; hsa-mir-4642 ; hsa-mir-4524b-5p ; hsa-mir-6774-5p ; hsa-let-7c-5p ; hsa-mir-6851-5p ; hsa-mir-3689d ; hsa-mir-490-5p ; hsa-mir-205-3p ; hsa-mir-4802-5p ; hsa-mir-4709-3p ; hsa-mir-3682-3p ; hsa-mir-765 ; hsa-mir-1272 ; hsa-mir-2277-3p ; hsa-mir-4423-3p ; hsa-mir-6870-3p ; hsa-mir-761 ; hsa-mir-3619-5p ; hsa-mir-214-3p ; hsa-mir-4762-5p ; hsa-mir-6165 ; hsa-mir-216a-5p ; hsa-mir-2113 ; hsa-mir-6509-5p ; hsa-mir-3924 ; hsa-mir-4672 ; hsa-mir-636 ; hsa-mir-616-3p ; hsa-mir-329-5p ; hsa-mir-4748 ; hsa-mir-4464 ; hsa-mir-6768-5p ; hsa-mir-218-5p ; hsa-mir-6839-3p ; hsa-mir-4507 ; hsa-mir-3940-5p ; hsa-mir-646 ; hsa-mir-503-5p ; hsa-mir-3156-3p ; hsa-mir-1260b ; hsa-mir-1260a ; hsa-mir-188-3p ; hsa-mir-5186 ; hsa-mir-4301 ; hsa-mir-150-5p ; hsa-mir-1236-3p ; hsa-mir-5093 ; hsa-mir-548aj-5p ; hsa-mir-548f-5p ; hsa-mir-548g-5p ; hsa-mir-548p ; hsa-mir-548x-5p ; hsa-mir-5584-5p

Nearest miRNA

hsa-mir-107/Upstream/554489; hsa-mir-1307/Downstream/403180;

Nearest TSS

Nearest CpG islands

None/Target, chr10-CpG: 68/Upstream/71518, chr10-CpG: 117/Downstream/201412

Upstream sequence

CCATTGTGGCTGTAGGAAAttttattttattttgagacattcttgctctgttgcccaggctggagtgcggtggtgcgatctcggcacactgcaacctctg

Downstream sequence

cttcccaggttcaagcaattctcctgcctcagcctcccgagtagctgggattacaggcgtgtgccaccatgccaggctaatattttatatttttagtaga