Basic Information
VIS ID
TVIS44020193
Fusion event
HTLV-1-SORCS3 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr10
Cytoband
q25.1
Reference genome
GRCh37/hg19
Start
106923444/105163686 (Hg38)
End
106923444/105163686 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA10D ; FRA10A ; FRA10B
Target gene
SORCS3
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-26b-5p
Nearest miRNA
hsa-mir-107/Upstream/895281; hsa-mir-202/Downstream/5734404;
Nearest TSS
ENST00000439456/Upstream/4758; ENST00000424701/Downstream/655511;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/520632, chr10-CpG: 100/Downstream/2000336
Upstream sequence
CTTTCTTTTTAATAAGCATAGCCACAAGGTGATGGAGTGCCAGGGGAAGAAAAAGAAGGGCAGAGAGGAGAGTGTGAAGGGATGGAAGCAGCAAGTATGG
Downstream sequence
TTGGTCTAGGCATAAGCCAGGTGACTTGTTTTGCTGCCATGCTTGATGGCCATGGTATGCTGAGTGTGGTCATCTTCTTCTGGGCACCGTATAATTTAGG
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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