Basic Information
VIS ID
TVIS44020212
Fusion event
HTLV-1-HTRA1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr10
Cytoband
q26.13
Reference genome
GRCh37/hg19
Start
124246086/122486570 (Hg38)
End
124246086/122486570 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA10D ; FRA10F ; FRA10A ; FRA10B
Target gene
HTRA1
miRNAs that regulate target gene
hsa-mir-155-5p ; hsa-mir-26b-5p ; hsa-mir-16-5p ; hsa-mir-6774-5p ; hsa-mir-635 ; hsa-mir-186-3p
Nearest miRNA
hsa-mir-107/Upstream/69503; hsa-mir-202/Downstream/2546213;
Nearest TSS
ENST00000439456/Upstream/25045; ENST00000420892/Downstream/20121;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/23846, chr10-CpG: 21/Downstream/156572
Nearest cancer related gene
HTRA1(TSG, No orient, 0)
Upstream sequence
GGGCTAGGACAGAAAACGGCCCTTTGTTCACAGAAGCGCTCTCACTTCCAAGAAAGCAAGCGTGGGAGAGGCAGGTGGTCCTCCCGATGTCCCTGTGCCC
Downstream sequence
CATGGTGTCAAGCTGGGTTACTATGGCCCTTCGTGACCCAGTGCAGCAGGGATGTGGGAACCAGTGGGTGTGAAGCTGTGACGGGTCACAAGAGGGCTGG
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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