Basic Information
VIS ID
TVIS44020214
Fusion event
HTLV-1-FAM53B integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr10
Cytoband
q26.13
Reference genome
GRCh37/hg19
Start
126380335/124691766 (Hg38)
End
126380335/124691766 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA10D ; FRA10F ; FRA10A ; FRA10B
Target gene
FAM53B
miRNAs that regulate target gene
hsa-mir-615-3p ; hsa-mir-6809-3p ; hsa-mir-6833-3p ; hsa-mir-4768-5p ; hsa-mir-4753-3p ; hsa-mir-627-3p ; hsa-mir-4778-3p ; hsa-mir-130b-5p ; hsa-mir-1236-3p ; hsa-mir-6515-3p ; hsa-mir-548c-3p ; hsa-mir-302d-5p ; hsa-mir-302b-5p ; hsa-mir-583 ; hsa-mir-1276 ; hsa-mir-4311 ; hsa-mir-3943 ; hsa-mir-4707-5p
Nearest miRNA
hsa-mir-107/Upstream/2274699; hsa-mir-202/Downstream/341017;
Nearest TSS
ENST00000439456/Upstream/68413; ENST00000611797/Downstream/11859;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/76122, chr10-CpG: 173/Downstream/50979
Upstream sequence
AATACAAATGCACTGAATGGCTGCAATTAGCCAAGGGTGGTGAATGGAGACTGCGCTCACTCCACTTGCCCTGTTTCACCAAAAAAGATCAAACTAGTAC
Downstream sequence
ACGTGTGACCCTGGGTCCCCCACTGCAAGTGGGAGAAGATGTGGAGGGAGCCTTGACTGAGAGTCCACGCGTGGCCCCGCTTCTCCCCACACAGGATGAC
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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