Basic Information
VIS ID
TVIS44020228
Fusion event
HTLV-1-ZNF511 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr10
Cytoband
q26.3
Reference genome
GRCh37/hg19
Start
135123102/133309598 (Hg38)
End
135123102/133309598 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA10D ; FRA10A ; FRA10B
Target gene
ZNF511
miRNAs that regulate target gene
hsa-mir-505-3p ; hsa-mir-100-5p
Nearest miRNA
hsa-mir-107/Upstream/61978; hsa-mir-3944/Downstream/61958;
Nearest TSS
ENST00000439456/Upstream/158; ENST00000463201/Downstream/2739;
Nearest CpG islands
chr10-CpG: 132/Target, None/Upstream, None/Downstream
Upstream sequence
CTGCGCCGCCTCCCTGACCGGTGCCTGGTCCCTGGGGCTGTGCTGCCGCTCTTCCATGTGCGGCCGCCCCACCGAGGCGCTGTGCCTGTCCAGCTTTGGC
Downstream sequence
GTGGCCGACTCTTCCACCACCTAGCCTGTTTGTGAAACTTAATTCATAAAAAGAGGGTTTGGGATTGCAAAAGATGCATAGGGGCTTTATTGGACGTCTC
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
Curate