Basic Information
VIS ID
TVIS44020249
Fusion event
HTLV-1-KIAA1217 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr10
Cytoband
p12.2
Reference genome
GRCh37/hg19
Start
24219350/23930421 (Hg38)
End
24219350/23930421 (Hg38)
Orient
-
Location type
Intronic
Target gene
KIAA1217
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-124-3p ; hsa-mir-4286 ; hsa-mir-6507-3p
Nearest miRNA
hsa-mir-1265/Upstream/2433780; hsa-mir-107/Downstream/345264;
Nearest TSS
ENST00000439456/Upstream/235639; ENST00000636305/Downstream/111710;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/234372, chr10-CpG: 209/Downstream/792247
Upstream sequence
GAAAAATGTCAACCTTCTATAACATCTGTTTCTATGTCATCTTATATAGTTATTATCTAAATATGCAAGCTAAAAAATTGTCGAAAGTCCTCATGAAGGG
Downstream sequence
TGGTGGTGCTTCCAAAGAGCTATGTCCACATTTGTTCTACATCCTGTATTATTTGCTCTCAACTCGGCAGCAGacattttttcacattcgaatgtttcta
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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