Basic Information
VIS ID
TVIS44020277
Fusion event
HTLV-1-RASSF4 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr10
Cytoband
q11.21
Reference genome
GRCh37/hg19
Start
45459978/44964530 (Hg38)
End
45459978/44964530 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA10G
Target gene
RASSF4
miRNAs that regulate target gene
hsa-mir-6876-3p ; hsa-mir-626 ; hsa-mir-8485 ; hsa-mir-6787-3p ; hsa-mir-4291 ; hsa-mir-761 ; hsa-mir-3619-5p ; hsa-mir-214-3p ; hsa-mir-922 ; hsa-mir-4312 ; hsa-mir-6882-3p ; hsa-mir-6754-5p ; hsa-mir-4441 ; hsa-mir-4270 ; hsa-mir-6510-5p ; hsa-mir-1301-3p ; hsa-mir-5047 ; hsa-mir-578 ; hsa-mir-7156-3p ; hsa-mir-8066 ; hsa-mir-8070 ; hsa-mir-147b ; hsa-mir-203b-5p ; hsa-mir-24-3p ; hsa-mir-2682-5p ; hsa-mir-34b-5p ; hsa-mir-3607-5p ; hsa-mir-3714 ; hsa-mir-4284 ; hsa-mir-4474-3p ; hsa-mir-449c-5p ; hsa-mir-4709-5p ; hsa-mir-548an ; hsa-mir-548au-3p ; hsa-mir-644a ; hsa-mir-6718-5p ; hsa-mir-6847-3p
Nearest miRNA
hsa-mir-1265/Upstream/1966849; hsa-mir-107/Downstream/199484;
Nearest TSS
ENST00000439456/Upstream/4691; ENST00000428466/Downstream/5639;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/4504, chr10-CpG: 19/Downstream/10044
Nearest cancer related gene
RASSF4(TSG, No orient, 0)
Upstream sequence
GCTTGGAGGAGGGGAGAGCCTGCTGGCCGACTTGGCCTGTCCAGCTGCATCTGTCACTCTGTGGTTTTTTGAGCCtgagcctgggtggcaggccagcccc
Downstream sequence
agcccatcctctcctgactcctgctgccacccatgcagcctcgctttaatccatttgtgtattgggcttctacctaggatctaatttcaagataaggttg
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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