Basic Information
VIS ID
TVIS44020320
Fusion event
HTLV-1-PALD1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr10
Cytoband
q22.1
Reference genome
GRCh37/hg19
Start
72236118/70476362 (Hg38)
End
72236118/70476362 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA10C
Target gene
PALD1
miRNAs that regulate target gene
hsa-mir-155-5p ; hsa-mir-196b-5p ; hsa-mir-197-3p ; hsa-let-7b-5p ; hsa-let-7a-5p ; hsa-mir-1305 ; hsa-mir-607 ; hsa-mir-4665-3p ; hsa-mir-3671 ; hsa-mir-6749-3p ; hsa-mir-6829-3p ; hsa-mir-6791-3p ; hsa-mir-7107-5p ; hsa-mir-1234-3p ; hsa-mir-5193 ; hsa-mir-6832-3p ; hsa-mir-6756-3p ; hsa-mir-3127-3p ; hsa-mir-1253 ; hsa-mir-140-3p ; hsa-mir-3175 ; hsa-mir-3200-5p ; hsa-mir-4251 ; hsa-mir-4329 ; hsa-mir-4434 ; hsa-mir-4516 ; hsa-mir-5004-5p ; hsa-mir-5197-3p ; hsa-mir-5703 ; hsa-mir-6758-5p ; hsa-mir-6761-5p ; hsa-mir-6856-5p ; hsa-mir-6878-5p
Nearest miRNA
hsa-mir-1265/Upstream/3072952; hsa-mir-107/Downstream/1314385;
Nearest TSS
ENST00000439456/Upstream/28411; ENST00000263563/Downstream/2459;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/17634, chr10-CpG: 133/Downstream/1543
Nearby gene
PALD1(No orient, 2446)
Upstream sequence
TCGACTGATTCTTTCGTTCTGCCTGGGGCTGGGGAGAGAGCAGGATGCCTTCTCTTGGGTGTACCCAGGGCTGCTCTGTGGCCTTCTCTCCTTCAACATT
Downstream sequence
CAGTCCTTGTTCCCCTCCCAGGCCCACGGTGGGGCAGATCTGACTGAATCTTTCTTGTGGTTGGGACTTTTCTAGCCCCATAGCCAGCAGACAGCCAGGG
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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