Basic Information
VIS ID
TVIS44020322
Fusion event
HTLV-1-ADAMTS14 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr10
Cytoband
q22.1
Reference genome
GRCh37/hg19
Start
72437747/70677991 (Hg38)
End
72437747/70677991 (Hg38)
Orient
+
Location type
Intronic
Target gene
ADAMTS14
miRNAs that regulate target gene
hsa-mir-6763-5p ; hsa-mir-3150a-3p ; hsa-mir-4314 ; hsa-mir-6845-5p ; hsa-mir-6762-5p ; hsa-mir-6825-5p ; hsa-mir-939-5p ; hsa-mir-1343-5p ; hsa-mir-3175 ; hsa-mir-8085 ; hsa-mir-6731-5p ; hsa-mir-3926 ; hsa-mir-423-5p ; hsa-mir-3184-5p ; hsa-mir-7155-5p ; hsa-mir-637 ; hsa-mir-8089 ; hsa-mir-4700-5p ; hsa-mir-4667-5p
Nearest miRNA
hsa-mir-1265/Upstream/3274581; hsa-mir-107/Downstream/1112756;
Nearest TSS
ENST00000439456/Upstream/5188; ENST00000486993/Downstream/94348;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/5009, chr10-CpG: 73/Downstream/137766
Upstream sequence
AAGATTGAACTCTGCATCTTTACATGGTCTCTGGATTTTAATCCCATATTCTCTAACATCTCAAATGCCAAAGtcattcatttcaaaaaatttgtactga
Downstream sequence
gtgctgaccatggacaaggtccacaggagatcataaagaaaatgaaagtgacacagATAATGACAGCAACAGTAACGGGTTCTTCCTGTGGCCCAGAcac
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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