Basic Information
VIS ID
TVIS44020337
Fusion event
HTLV-1-ACTA2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr10
Cytoband
q23.31
Reference genome
GRCh37/hg19
Start
90725055/88965298 (Hg38)
End
90725055/88965298 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA10D
Target gene
ACTA2
miRNAs that regulate target gene
hsa-mir-484
Nearest miRNA
hsa-mir-1265/Upstream/1461344; hsa-mir-107/Downstream/98037;
Nearest TSS
ENST00000439456/Upstream/12525; ENST00000460510/Downstream/25284;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/84432, chr10-CpG: 68/Downstream/25238
Upstream sequence
CACATTTGCAGTATATTCACCATTAGGTTGTAAACTTTTGGAGGCAGCCAGTGTGTTCATTTTTCCCTTAGGGCACCCTGCCCTTCTACATATAGTAGAA
Downstream sequence
ACTCAGGAATTTGGTTAAGCAACTTTCTATTTTCCCCAAACCTTAAAAGAGCTGTCTGCAATGACCATCTCAGACGTTGTTAGTTTCAGAAAGTTTCCCT
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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