Basic Information
VIS ID
TVIS44020343
Fusion event
HTLV-1-ALDH18A1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr10
Cytoband
q24.1
Reference genome
GRCh37/hg19
Start
97414534/95654777 (Hg38)
End
97414534/95654777 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA10D
Target gene
ALDH18A1
miRNAs that regulate target gene
hsa-mir-124-3p ; hsa-mir-16-5p ; hsa-mir-744-5p ; hsa-mir-20a-5p ; hsa-mir-576-5p ; hsa-mir-4263 ; hsa-mir-4799-5p ; hsa-mir-3124-3p ; hsa-mir-4762-5p ; hsa-mir-4282 ; hsa-mir-4709-3p
Nearest miRNA
hsa-mir-107/Upstream/6061950; hsa-mir-1287/Downstream/409538;
Nearest TSS
ENST00000439456/Upstream/25924; ENST00000461927/Downstream/1832;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/93051, chr10-CpG: 94/Downstream/1326
Upstream sequence
TGCAGCTGTTCTAAAACATATGGCATCTAGTAGGCAACAGAAAGTATTAATTGATCTTTGTTATTTCAATTTTTTCATAACACTGAAGTATGATTTTAGC
Downstream sequence
ACGTGATCTAAGTTTGCTGCTTATATAAATTCCTTCAATAATGGCTGCTAAACAATTATTTACATGTGAATTCTCCAAAATAACTACAGAAGAGCCAAAG
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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