Basic Information
VIS ID
TVIS44020347
Fusion event
HTLV-1-PGR integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr11
Cytoband
q22.1
Reference genome
GRCh37/hg19
Start
100957019/101086288 (Hg38)
End
100957019/101086288 (Hg38)
Orient
-
Location type
Intronic
Target gene
PGR
miRNAs that regulate target gene
hsa-mir-126-3p ; hsa-mir-181a-5p ; hsa-mir-378a-3p
Nearest miRNA
hsa-mir-10392/Upstream/4744762; hsa-let-7a-2/Downstream/433532;
Nearest TSS
ENST00000527297/Upstream/22263; ENST00000532529/Downstream/40800;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/398618, chr11-CpG: 170/Downstream/41011
Nearest cancer related gene
PGR(TSG, No orient, 0)
Upstream sequence
aaaattctcaacaaaacactagcaaaccaaatcaaacatcaaagttaatttaccacgatcaagttggcttcactcctggtatggaaggttagctcaatat
Downstream sequence
atgcaaatcaataaatatgatttaccacatgagaagaattaaaaataaaaccatatgatcatctcaatagacacagaaacagctttcgataaaatgcaat
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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