Basic Information
VIS ID
TVIS44020354
Fusion event
HTLV-1-EXPH5 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr11
Cytoband
q22.3
Reference genome
GRCh37/hg19
Start
108449658/108578931 (Hg38)
End
108449658/108578931 (Hg38)
Orient
-
Location type
Intronic
Target gene
EXPH5
miRNAs that regulate target gene
hsa-mir-877-3p ; hsa-let-7a-5p ; hsa-mir-129-5p ; hsa-mir-557 ; hsa-mir-507 ; hsa-mir-450b-5p ; hsa-mir-4738-3p ; hsa-mir-4299 ; hsa-mir-3145-5p ; hsa-mir-18a-5p ; hsa-mir-1225-3p ; hsa-mir-1233-3p ; hsa-mir-1247-3p ; hsa-mir-1262 ; hsa-mir-1323 ; hsa-mir-4701-3p ; hsa-mir-542-3p ; hsa-mir-548o-3p ; hsa-mir-548p ; hsa-mir-658 ; hsa-mir-6736-5p ; hsa-mir-6742-3p ; hsa-mir-6776-5p
Nearest miRNA
hsa-mir-10392/Upstream/4728951; hsa-let-7a-2/Downstream/2768826;
Nearest TSS
ENST00000527297/Upstream/10805; ENST00000534774/Downstream/14716;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/80251, chr11-CpG: 54/Downstream/13940
Upstream sequence
gatttttgtatggtgattttgtatcctgcaacttgactgaattcttttatcagttctaacagcttttttgcagagtctttaggatttttgttttaaatgt
Downstream sequence
aagatcatattgtctgaaaacaagaacaatgatttctttctttccaatttggatgccctttatttctttctcttgcctaattgctctagctaggacttcc
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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