Basic Information
VIS ID
TVIS44020355
Fusion event
HTLV-1-DDX10 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr11
Cytoband
q22.3
Reference genome
GRCh37/hg19
Start
108623792/108753065 (Hg38)
End
108623792/108753065 (Hg38)
Orient
-
Location type
Intronic
Target gene
DDX10
miRNAs that regulate target gene
hsa-mir-155-5p ; hsa-mir-34a-5p ; hsa-mir-98-5p ; hsa-mir-30a-5p ; hsa-let-7b-5p
Nearest miRNA
hsa-mir-10392/Upstream/4903085; hsa-let-7a-2/Downstream/2594692;
Nearest TSS
ENST00000527297/Upstream/87943; ENST00000534439/Downstream/14249;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/87596, chr11-CpG: 65/Downstream/669728
Upstream sequence
tgtgctaaataaatatttgctgaattgaatTCTGCTAGCCAAGCTATAATGTTGGAAAATGTACCACTCTTTGTCATAAATTGGAAATGTGCTTTGTATA
Downstream sequence
TATGACCAGTGACTATTAGGAGTCTTTATTTCAGAAGGGAGAACTCTATAATGCATAAAATTTCTGCAAACCAAATGTGTGTTTAATTGTTTTCTACAGA
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
Curate