Basic Information
VIS ID
TVIS44020361
Fusion event
HTLV-1-ZBTB16 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr11
Cytoband
q23.2
Reference genome
GRCh37/hg19
Start
114057311/114186589 (Hg38)
End
114057311/114186589 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA11G
Target gene
ZBTB16
miRNAs that regulate target gene
hsa-mir-1277-5p ; hsa-mir-6083 ; hsa-mir-5580-3p ; hsa-mir-190a-3p ; hsa-mir-301b-3p ; hsa-mir-3145-3p ; hsa-mir-186-3p ; hsa-mir-5685 ; hsa-mir-4699-3p ; hsa-mir-4690-3p ; hsa-mir-3908 ; hsa-mir-330-3p ; hsa-mir-424-5p ; hsa-mir-497-5p ; hsa-mir-15a-5p ; hsa-mir-6838-5p ; hsa-mir-16-5p ; hsa-mir-195-5p ; hsa-mir-15b-5p ; hsa-mir-6783-3p ; hsa-mir-1343-3p ; hsa-mir-6749-3p ; hsa-mir-452-3p ; hsa-mir-24-3p ; hsa-mir-4284 ; hsa-mir-1976 ; hsa-mir-3653-5p ; hsa-mir-4685-3p ; hsa-mir-4287 ; hsa-mir-4469 ; hsa-mir-6742-3p ; hsa-mir-6852-5p ; hsa-mir-939-3p ; hsa-mir-5088-3p ; hsa-mir-5193 ; hsa-mir-1470 ; hsa-mir-4667-3p ; hsa-mir-1306-5p ; hsa-mir-5011-5p ; hsa-mir-6778-3p ; hsa-mir-3162-3p ; hsa-mir-361-3p ; hsa-mir-6849-3p
Nearest miRNA
hsa-mir-10392/Upstream/736501; hsa-let-7a-2/Downstream/4457411;
Nearest TSS
ENST00000527297/Upstream/5823; ENST00000535509/Downstream/50618;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/103472, chr11-CpG: 24/Downstream/12552
Nearest cancer related gene
ZBTB16(OG, No orient, 0)
Upstream sequence
tgagtttagttttggacacactgagtcagaggtccccatggacatccaggttgaggtatgtcagcaattCTTACATTCCCATAAAGTACAGTTTAGGCAA
Downstream sequence
CAGGGCACATTTCCCTGTGTTGGTATCATTTTTCTCCTGTCCCCCCCATCACCTGGAGCTAGGTCTTCAGATCCTCCTTCTTCTTGAGGTATCTAACTTG
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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