Basic Information
VIS ID
TVIS44020364
Fusion event
HTLV-1-CADM1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr11
Cytoband
q23.3
Reference genome
GRCh37/hg19
Start
115318508/115447789 (Hg38)
End
115318508/115447789 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA11G ; FRA11B
Target gene
CADM1
miRNAs that regulate target gene
hsa-mir-15a-5p ; hsa-mir-192-5p ; hsa-mir-16-5p ; hsa-mir-26b-5p ; hsa-mir-877-3p ; hsa-mir-484 ; hsa-mir-182-5p ; hsa-let-7a-2-3p ; hsa-let-7g-3p ; hsa-mir-214-3p ; hsa-mir-486-5p ; hsa-mir-4644 ; hsa-mir-4306 ; hsa-mir-185-5p ; hsa-mir-4479 ; hsa-mir-6770-5p ; hsa-mir-361-3p ; hsa-mir-4428 ; hsa-mir-6885-3p ; hsa-mir-1273e ; hsa-mir-6892-5p ; hsa-mir-4327 ; hsa-mir-6512-5p ; hsa-mir-4475 ; hsa-mir-4484 ; hsa-mir-6768-3p ; hsa-mir-548an ; hsa-mir-3692-3p ; hsa-mir-4703-3p ; hsa-mir-140-3p ; hsa-mir-7852-3p ; hsa-mir-144-3p ; hsa-mir-101-3p ; hsa-mir-6732-3p ; hsa-mir-652-5p ; hsa-mir-10b-5p ; hsa-mir-10a-5p ; hsa-mir-1277-5p ; hsa-mir-6083 ; hsa-mir-190a-3p ; hsa-mir-5011-5p ; hsa-mir-7161-3p ; hsa-mir-126-3p ; hsa-mir-21-5p ; hsa-mir-302c-5p ; hsa-mir-552-5p
Nearest miRNA
hsa-mir-10392/Upstream/1997701; hsa-let-7a-2/Downstream/3196211;
Nearest TSS
ENST00000527297/Upstream/84160; ENST00000306533/Downstream/56600;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/293565, chr11-CpG: 178/Downstream/55067
Nearest cancer related gene
CADM1(TSG, No orient, 0)
Upstream sequence
aaacggtggctggtagctttgctggcaccctcctcagacaattttgtatcagagtgcctccaaagagacaccttctcatgaatggttttccccagcatat
Downstream sequence
tagagggtggaattccagcaagtttcacagcaccacagcaacttctctgccacagtgagccatagctgtgtcctctccaatactacctggatctcagctt
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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