Basic Information
VIS ID
TVIS44020374
Fusion event
HTLV-1-GRAMD1B integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr11
Cytoband
q24.1
Reference genome
GRCh37/hg19
Start
123252383/123381675 (Hg38)
End
123252383/123381675 (Hg38)
Orient
+
Location type
Intronic
Target gene
GRAMD1B
miRNAs that regulate target gene
hsa-mir-1277-5p ; hsa-mir-3686 ; hsa-mir-6083 ; hsa-mir-190a-3p ; hsa-mir-601 ; hsa-mir-4778-5p ; hsa-mir-4742-3p ; hsa-mir-8076 ; hsa-mir-5011-5p ; hsa-mir-6873-3p ; hsa-mir-4436b-5p ; hsa-mir-6509-3p ; hsa-mir-1236-3p ; hsa-mir-6515-3p ; hsa-mir-6817-3p ; hsa-mir-7110-3p ; hsa-mir-1273g-3p ; hsa-mir-181a-2-3p ; hsa-mir-99b-3p ; hsa-mir-99a-3p ; hsa-mir-2861 ; hsa-mir-1238-3p ; hsa-mir-670-3p ; hsa-mir-4279 ; hsa-mir-6881-3p ; hsa-mir-6749-3p ; hsa-mir-6792-3p ; hsa-mir-4691-5p ; hsa-mir-2116-3p ; hsa-mir-877-3p ; hsa-mir-32-5p ; hsa-mir-92b-3p ; hsa-mir-92a-3p ; hsa-mir-1227-5p ; hsa-mir-128-1-5p ; hsa-mir-128-2-5p ; hsa-mir-2278 ; hsa-mir-4640-5p ; hsa-mir-4726-5p ; hsa-mir-4786-5p ; hsa-mir-6165 ; hsa-mir-6501-3p ; hsa-mir-6762-5p ; hsa-mir-6845-5p
Nearest miRNA
hsa-let-7a-2/Upstream/163; hsa-mir-3167/Downstream/3606783;
Nearest TSS
ENST00000527297/Upstream/23247; ENST00000533341/Downstream/48675;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/22911, chr11-CpG: 90/Downstream/48666
Nearby gene
MIR4493(-163) ;
Upstream sequence
TTAACATGCTGGAACTGGAAGGGATTCAGAGTCGAGGTTCTAATATATAGGTTGAAGGTTcctggaggactgcagagttacagcaaaggctctaagaggc
Downstream sequence
catgtgtgcactgaatgctgcctggggaacaaatacatCAACGTGGTCACCATCTCTTGGAACTATGCTATTTTTTTAAATGATAAAAATTAATCCCATA
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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