Basic Information
VIS ID
TVIS44020376
Fusion event
HTLV-1-ZNF202 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr11
Cytoband
q24.1
Reference genome
GRCh37/hg19
Start
123602765/123732057 (Hg38)
End
123602765/123732057 (Hg38)
Orient
+
Location type
Intronic
Target gene
ZNF202
miRNAs that regulate target gene
hsa-mir-130b-3p ; hsa-mir-98-5p ; hsa-mir-93-5p ; hsa-mir-484 ; hsa-mir-3653-3p ; hsa-mir-5011-3p ; hsa-mir-15b-3p ; hsa-mir-1324 ; hsa-mir-519c-3p ; hsa-mir-519b-3p ; hsa-mir-519a-3p ; hsa-mir-651-3p ; hsa-mir-519d-3p ; hsa-mir-20b-5p ; hsa-mir-20a-5p ; hsa-mir-17-5p ; hsa-mir-106b-5p ; hsa-mir-526b-3p ; hsa-mir-106a-5p ; hsa-mir-4310 ; hsa-mir-7157-5p ; hsa-mir-629-3p ; hsa-mir-4279
Nearest miRNA
hsa-let-7a-2/Upstream/350545; hsa-mir-3167/Downstream/3256401;
Nearest TSS
ENST00000527297/Upstream/63558; ENST00000321355/Downstream/9557;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/77080, chr11-CpG: 57/Downstream/9133
Upstream sequence
TATCACCTGGTTATAAAAAATGCATTGCTGATCTCCCTACAACAGGGTGTCTTTTCAGTCTTCCATGTCTTTTTGAAGGTTGTTCCTTCTGCACAGGCTA
Downstream sequence
CTCTCCACCCTTCTCCTTTCCACGCTACATGGTGTGTTCTCTTTCTTTTTAACGGGTCTTGTCTTTATTCCCACAATTTACAGCTTAGGTCCCTCTCACT
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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