Basic Information
VIS ID
TVIS44020385
Fusion event
HTLV-1-NTM integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr11
Cytoband
q25
Reference genome
GRCh37/hg19
Start
131476053/131606159 (Hg38)
End
131476053/131606159 (Hg38)
Orient
+
Location type
Intronic
Target gene
NTM
miRNAs that regulate target gene
hsa-mir-182-5p ; hsa-mir-340-5p ; hsa-mir-501-5p ; hsa-mir-500b-5p ; hsa-mir-362-5p
Nearest miRNA
hsa-let-7a-2/Upstream/939356; hsa-mir-4697/Downstream/2292345;
Nearest TSS
ENST00000527297/Upstream/24148; ENST00000470371/Downstream/57424;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/689420, chr11-CpG: 16/Downstream/84303
Upstream sequence
ttgagatagggtctgtctctgtcattcaggctggagtgcagtggtgccatcgcagttcactgtagcctcaacctccctggctaaagtgatttgcctacct
Downstream sequence
cagccaccctggctcaagtgatttacccaccttcaggcacacaccaccatgctggtgtatttaaaaaaatttgttttgtagagataggctctcagcatgt
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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