Basic Information
VIS ID
TVIS44020386
Fusion event
HTLV-1-OPCML integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr11
Cytoband
q25
Reference genome
GRCh37/hg19
Start
132417029/132547134 (Hg38)
End
132417029/132547134 (Hg38)
Orient
+
Location type
Intronic
Target gene
OPCML
miRNAs that regulate target gene
hsa-mir-3149 ; hsa-mir-297 ; hsa-mir-675-3p ; hsa-mir-3924 ; hsa-mir-8068 ; hsa-mir-190a-3p ; hsa-mir-567 ; hsa-mir-4307 ; hsa-mir-5011-5p
Nearest miRNA
hsa-let-7a-2/Upstream/1880331; hsa-mir-4697/Downstream/1351370;
Nearest TSS
ENST00000527297/Upstream/214644; ENST00000532272/Downstream/313643;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/635496, chr11-CpG: 33/Downstream/395633
Nearest cancer related gene
OPCML(TSG, No orient, 0)
Upstream sequence
TTGGGTGCAAACATAAAGGCCACTTTAAAAATATGTCACCAGAGAAAATGTCAAAGGCTTTTGGGACACAGCAAGATGACAAGGGCAAAAACCATGCTTG
Downstream sequence
GCACATACTCAGTGGGGAAGCAGGCACTCACTTTATTTGAATTAAAATTGATGAAATACCTTCTTCCCTCTTTGAAAAGTGCTGGGAAATTCTACAGTTT
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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