Basic Information
VIS ID
TVIS44020389
Fusion event
HTLV-1-IGSF9B integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr11
Cytoband
q25
Reference genome
GRCh37/hg19
Start
133792588/133922693 (Hg38)
End
133792588/133922693 (Hg38)
Orient
+
Location type
Exonic
Target gene
IGSF9B
miRNAs that regulate target gene
hsa-mir-10a-5p ; hsa-mir-1305 ; hsa-mir-6809-3p ; hsa-mir-6833-3p ; hsa-mir-4768-5p ; hsa-mir-607 ; hsa-mir-4753-3p ; hsa-mir-6873-3p ; hsa-mir-627-3p ; hsa-mir-130b-5p ; hsa-mir-6817-3p ; hsa-mir-7110-3p ; hsa-mir-5685 ; hsa-mir-4690-3p ; hsa-mir-500b-3p ; hsa-mir-3613-3p ; hsa-mir-4668-3p ; hsa-mir-548c-3p ; hsa-mir-129-5p ; hsa-mir-4715-3p ; hsa-mir-1227-3p ; hsa-mir-365b-5p ; hsa-mir-365a-5p ; hsa-mir-8052 ; hsa-mir-3199 ; hsa-mir-4487 ; hsa-mir-6872-3p ; hsa-mir-455-5p ; hsa-mir-1295b-3p ; hsa-mir-625-3p
Nearest miRNA
hsa-let-7a-2/Upstream/24112;
Nearest TSS
ENST00000527297/Upstream/10331; ENST00000532272/Downstream/15407;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/1320, chr11-CpG: 21/Downstream/8096
Upstream sequence
GCGCTGCTTGTTGACAAAGCAGGCAGCCAGGGTGCTGAACAGGATGGCAGCTGCCAAGAAGCAGATGGTAGCTACGATTCCCGCCAGCACAGGCCGCGCC
Downstream sequence
AGCCCATCCTCGGTCAGGTCCGGCTGCGGGAAGATGTCTGCAGGGAGGGTGGGGAGCACTCATGAGCCCATCCTTCCCCGGGACCTCACCTGCTCCGACC
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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