Basic Information
VIS ID
TVIS44020393
Fusion event
HTLV-1-SOX6 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr11
Cytoband
p15.2
Reference genome
GRCh37/hg19
Start
16135902/16114356 (Hg38)
End
16135902/16114356 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA11I
Target gene
SOX6
miRNAs that regulate target gene
hsa-mir-1-3p ; hsa-mir-499a-5p ; hsa-mir-155-5p ; hsa-mir-16-5p ; hsa-mir-208a-3p ; hsa-mir-3148 ; hsa-mir-4668-5p ; hsa-mir-562 ; hsa-mir-651-3p ; hsa-mir-548n ; hsa-mir-19a-3p ; hsa-mir-19b-3p ; hsa-mir-1269a ; hsa-mir-132-3p ; hsa-mir-202-3p ; hsa-mir-1273h-5p ; hsa-mir-129-5p ; hsa-mir-30b-3p ; hsa-mir-30c-1-3p ; hsa-mir-30c-2-3p ; hsa-mir-3122 ; hsa-mir-3689a-3p ; hsa-mir-3689b-3p ; hsa-mir-3689c ; hsa-mir-3913-5p ; hsa-mir-450a-1-3p ; hsa-mir-6513-5p ; hsa-mir-6731-5p ; hsa-mir-6779-5p ; hsa-mir-6780a-5p ; hsa-mir-6788-5p ; hsa-mir-6878-5p ; hsa-mir-8085 ; hsa-mir-887-5p
Nearest miRNA
hsa-mir-210/Upstream/144735; hsa-let-7a-2/Downstream/2273431;
Nearest TSS
ENST00000527297/Upstream/2487; ENST00000525106/Downstream/138180;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/172679, chr11-CpG: 101/Downstream/490150
Upstream sequence
CCTCTAAAggccttgttggcaaaaagtctgaactcaaatctatatgctgctattttcttgactgtgtaatcttgaacagttacttaattgttctgagtct
Downstream sequence
atttcttcatgtaaaaactgaagctaattataataccttacacaattattgtgaggaccaaatagacaataaaagtatctcttgtggcacagtacctgac
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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