Basic Information
VIS ID
TVIS44020397
Fusion event
HTLV-1-USH1C integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr11
Cytoband
p15.1
Reference genome
GRCh37/hg19
Start
17565238/17543691 (Hg38)
End
17565238/17543691 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA11C ; FRA11I
Target gene
USH1C
miRNAs that regulate target gene
hsa-mir-335-5p
Nearest miRNA
hsa-mir-210/Upstream/1574070; hsa-let-7a-2/Downstream/844096;
Nearest TSS
ENST00000527297/Upstream/9817; ENST00000428619/Downstream/616;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/66612, chr11-CpG: 30/Downstream/528
Upstream sequence
CTTGAGAATCCCAGACCACCAGTGAGGCCCCTCACTGGGACACACCAGGGTGGACCCGGCTCTGCCTGAAGGATCTGGCCGGCCAGAGCCCAGCTCCGAC
Downstream sequence
GCCCTCAGTACCTCCTCCCTTCCTCCCCACCGCACCCGGGTCAGCACCAGCTCCTCAGCTACTTCTCAGACCCTAAGAAACGCCCTTAGGCAGGCAGGGC
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
Curate