Basic Information
VIS ID
TVIS44020404
Fusion event
HTLV-1-GAS2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr11
Cytoband
p14.3
Reference genome
GRCh37/hg19
Start
22710238/22688692 (Hg38)
End
22710238/22688692 (Hg38)
Orient
+
Location type
Intronic
Target gene
GAS2
miRNAs that regulate target gene
hsa-mir-26b-5p
Nearest miRNA
hsa-mir-210/Upstream/2928609; hsa-let-7a-2/Downstream/730413;
Nearest TSS
ENST00000527297/Upstream/13919; ENST00000526665/Downstream/66956;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/21621, chr11-CpG: 60/Downstream/140527
Upstream sequence
aatattataatttttataataaaactataaaaCAAAAAGAAAAGAATTTTTTTCAGTTAGTAAAACTGCAGCAAGTTATTAAACTTGAAATAGTTCCGTG
Downstream sequence
AACCTGAGCAAATTTTTAACTGAATATAAAGCTAAATTTTTTTCTGATTGTGATAAAGGTTTTAGTATAAAACCTTAAATGTGTTACTTGAACAAGTGGA
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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